Identification of Tongue Involvement in Late-Onset Pompe Disease

Inclusion Criteria: * age ≥ 12 years * confirmed diagnosis of LOPD and naïve to enzyme-replacement therapy (ERT) * acquired/hereditary myopathy (e.g., dermatomyositis, polymyositis, inclusion body myositis, limb-girdle muscular dystrophy, distal myopathy, myotonic muscular dystrophy, and other myopathy) * neuropathy (e.g., peripheral neuropathy, cranial neuropathy, autonomic neuropathy, focal neuropathy) Exclusion Criteria: * current use, history within the past two years of use, or eligible but declined use of Lumizyme® enzyme replacement therapy (applicable to LOPD group) * history of stroke, Parkinson's disease, oculopharyngeal muscular dystrophy, head and neck cancer or radiation treatment to head/neck, or other conditions that commonly affect lingual strength * inability to follow directions for study participation