Active — Not RecruitingNot Applicable

Cryptosporidiosis and Enteropathogens in Bangladesh

Bangladesh150 participantsStarted 2024-10-01

Plain-language summary

The purpose of this study is to explore the role of anti-parasite antibody in protection of children from the parasitic infection cryptosporidiosis. This work has the promise of identifying immune pathways important for protection from parasitic infections of the gut, and will help with designing a vaccine to prevent this infection estimated to cause, from diarrhea and malnutrition, an overall burden of 12 million disability-adjusted life-years in children.

Who can participate

Age range1 Day – 7 Days

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Mother willing to sign informed consent form. * Healthy infant * No obvious congenital abnormalities or birth defects. * Stable household with no plans to leave the area for the next one year. Exclusion Criteria: * Parents are not willing to have child's blood drawn. * Parents are planning to enroll child into another interventional clinical study during the time period of this trial that could affect the outcomes of this study. * Mother not willing to have blood drawn and breast milk extracted. * Parents not willing to have field research assistant in home two times per week. * History of seizures or other apparent neurologic disorders. * Infant has any sibling currently or previously enrolled in this study, including a twin.

What they're measuring

Functional characterization of anti-Cryptosporidium antibodies associated with protection

Timeframe: Birth until 4 years

Trial details

NCT IDNCT02764918

SponsorUniversity of Virginia

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-10

View on ClinicalTrials.gov More Cryptosporidiosis trials