Dose Escalation Versus Standard in Laryngopharyngeal Cancers

LH Inclusion Criteria ALL of the following inclusion criteria must be met * Histologically confirmed squamous cell cancer of the larynx or hypopharynx * Radiotherapy with concomitant chemotherapy as primary therapy * Induction chemotherapy is permitted * TNM Stage T3-4, N0-3, M0 or T1/2 with N2-3 disease (Stage III or IV a/b) disease * WHO performance status of 0 or 1 * Creatinine clearance of more than 50ml/min * All patients must be suitable to attend regular follow up OPC inclusion criteria ALL of the following inclusion criteria must be met * Histologically confirmed squamous cell cancer of the oropharynx * Radiotherapy with concomitant chemotherapy as primary therapy * Induction chemotherapy is permitted * WHO performance status of 0 or 1 * Creatinine clearance of more than 50ml/min * All patients must be suitable to attend regular follow up * And any of the stage of disease as seen below HPV (p16) negative: TNM Stage T2-T4, any N stage, M0 disease HPV (p16) Positive: more than 10 pack year history and N2b or N3 disease LH Exclusion Criteria The patient is ineligible if ANYONE of the following exclusion criteria is met * Previous radiotherapy to the head and neck region * Previous malignancy except non-melanoma skin cancer and early stage cancer in remission for at least 5 years following treatment * Previous or concurrent illness, which in the investigator's opinion would interfere with either completion of therapy or follow-up * Pre-existing previous speech or swa…