TerminatedEarly Phase 1

Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders

Stopped: Funding is no longer available due to the failure to enroll the target number of participants within the required timeframe.

Canada10 participantsStarted 2020-11-10

Plain-language summary

The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used. This study will take place at TBRHSC in the Cardiorespiratory Department and in the Research MRI facility.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. A healthy volunteer (i.e.: someone not diagnosed with a lung disorder written below; this may include smokers who have not been diagnosed with a lung disorder) or
✓. Has been diagnosed with one of the following respiratory disorders: lung transplants, lung resection, lung cancer, asthma, cystic fibrosis, chronic obstructive pulmonary disease, emphysema, mesothelioma, asbestosis, pulmonary embolism, interstitial lung disease, pulmonary fibrosis, bronchiectasis, seasonal allergies, pneumonia, cold virus, lung infection, pulmonary hypertension, pulmonary dysplasia, obstructive sleep apnea
✓. Healthy volunteers enrolled in this study must be able to hold their breath for 25 seconds
✓. Lung disorder participants must be able to hold their breath for 15 seconds

What they're measuring

Signal to Noise Ratio

Timeframe: 2 years

Trial details

NCT IDNCT02748798

SponsorThunder Bay Regional Health Research Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-10-16

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