CompletedNot Applicable

Transcranial Direct Current Stimulation (tDCS) as a Treatment for Cognitive Deficits in Schizophrenic

China49 participantsStarted 2015-12-01

Plain-language summary

This trial attempts to evaluate the effects of intensive transcranial direct-current stimulation (tDCS) on improving cognition in schizophrenia patients and changes in resting state brain network connectivity, especially increasing connectivity in the tasks related network, and increasing activation the DLPFC in a working memory task. Half of the participants will be randomized to tDCS group, while the other half will be randomized to receive sham tDCS.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion Criteria: * Subjects who have cognitive deficits as indicated by a score of \< 85 on RBANS, and meet criteria for DSM-5 diagnosis of chronic SZ, schizoaffective disorder (SA), or schizophreniform disorder (SZF), and who are stably treated with antipsychotic medications and are not in acute exacerbation of illness symptoms. Exclusion Criteria: * Patients with risk factors for an MRI scan, seizure disorder, and for women of childbearing age who are pregnant or regularly engaging in sexual activity and not regularly using an acceptable birth control method (systemic or double-barrier).

What they're measuring

The MATRICS Consensus Cognitive Battery (MCCB)

Timeframe: Change from Baseline MCCB through study completion, an average of 15 days

Neuroimage changes in Magnetic Resonance Imaging (MRI)

Timeframe: Change from Baseline MCCB through study completion, an average of 15 days

Trial details

NCT IDNCT02748083

SponsorShanghai Mental Health Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-09-01

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