Stopped: Grant ended, slow accrual- enrollment goal not met.
In order to better understand radiation-induced lung toxicity, the investigator proposes a novel functional avoidance approach that incorporates central as well as peripheral BSS segments in the treatment planning process in order to quantify and account for their respective radiosensitivities. Specifically, the investigator proposes a systematic study that involves acquiring pre- and post-SAbR high-resolution CT and SPECT V/Q scans from lung cancer patients who receive radiotherapy, followed by auto-segmentation of the BSS elements using virtual bronchoscopy.
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Number of patients that show an association between radiation-induced collapse of branching serial structures elements and localized change in pulmonary function
Timeframe: 3 years
Radiosensitivity of peripheral BSS segments in terms of dose dependent probability of collapse.
Timeframe: 3 years