Developing Rectal USPE Measures for Suppositories (Project DRUM-S)

All participants must meet all of the inclusion criteria to participate in this study. Inclusion Criteria: All participants must meet all of the inclusion criteria to participate in this study. * Eligible male participants must be 18 years of age or older * Eligible female participants must be 18-45 years of age Inclusion criteria include men and women who: * Report receptive anal intercourse (RAI) at least twice in the past 6 months * Are willing to use each study product in conjunction with RAI on at least one occasion in each data collection period (resulting in a minimum of 3 RAI events during each product evaluation period; on average every 2 weeks, all 3 products across an average of 6 -12 weeks) * Are willing and able to respond to study data collection systems via phone and internet, attend all study visits, and participate in in-depth qualitative interviews Additional Inclusion Criteria for Female Volunteers: * Report vaginal-penile intercourse (VI) at least twice in the past 6 months * Willing to use each study suppository formulation in conjunction with VI on at least one occasion in each data collection period (resulting in a minimum of 2 vaginal intercourse events during the course of the study) * Report consistent use of an effective birth control method: e.g., hormonal contraceptive, IUD, bilateral tubal ligation, Essure® or any non-incisional permanent birth control procedure, hysterectomy (partial or total, with/without oophorectomy), partner's vasecto…