CompletedNot Applicable

Imaging of Lymphatic Anomalies

United States10 participantsStarted 2016-04

Plain-language summary

Lymphatic Anomalies (LA) is characterized by proliferation of lymphatic tissue causing deterioration of pulmonary function. Understanding changes in lymphatic anatomy in these patients is hindered by the difficulty of imaging the lymphatic system. Dynamic Contrast Enhanced MR Lymphangiogram (DCMRL) may be useful in investigating pathological changes in the lymphatic system.

Who can participate

Age range2 Years – 80 Years

SexALL

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Inclusion Criteria: * Subjects diagnosed with Lymphatic Anomalies (GLA, KL, Gorham disease) with radiological and or pathological confirmation of lung involvement will be considered for the study. * Girls \> 11 y.o. with a negative urine pregnancy test and contraception use. * Registration in the International Lymphangiomatosis and Gorham's Disease Alliance (LGDA) Patient Registry or referral by a physician. Exclusion Criteria: * Subjects with contraindications to contrast enhanced MRI: allergy to gadolinium imaging agents, impaired renal function (GFR\<30) and presence of paramagnetic objects. * Claustrophobia or contraindications to sedation/anesthesia * Uncorrectable coagulopathy (bleeding disorders). * Pregnant or lactating females.

What they're measuring

Describe lymphatic anatomy of participants with lymphatic anomalies (LA)

Timeframe: 2 Days

Trial details

NCT IDNCT02744027

SponsorChildren's Hospital of Philadelphia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-12

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