The purpose of this trial is to study the effect that anemia and red blood cell (RBC) transfusions have on oxygen levels in the digestive tracts of extremely low birth weight (ELBW) infants and to look for possible markers in a baby's blood, urine and/or stool that may lead to a better understanding of what makes an ELBW infant at risk for digestive tract problems such as necrotizing enterocolitis.
Age range
1 Day – 5 Days
Sex
ALL
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Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Mesenteric Tissue Oxygenation
Timeframe: 60 Minutes prior to transfusion to 48 hours after transfusion
Infants Developing TR-NEC
Timeframe: 60 Minutes prior to transfusion to 48 hours after transfusion
Inhibition of NO-Mediated Vasodilation
Timeframe: 60 Minutes prior to transfusion to 48 hours after transfusion
Metabolic Changes of Red Blood Cells
Timeframe: 60 Minutes prior to transfusion to 48 hours after transfusion
Mesenteric Tissue Oxygenation During the NEC Window Period
Timeframe: 28 to 34 Weeks Post Menstrual Age
Immune Cell Function
Timeframe: Up to 90 days of age
Microbial Changes
Timeframe: Up to 90 days of age
Serum Cytokine Levels
Timeframe: Up to 90 days of age