The purpose of this trial is to study the effect that anemia and red blood cell (RBC) transfusions have on oxygen levels in the digestive tracts of extremely low birth weight (ELBW) infants and to look for possible markers in a baby's blood, urine and/or stool that may lead to a better understanding of what makes an ELBW infant at risk for digestive tract problems such as necrotizing enterocolitis.
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Mesenteric Tissue Oxygenation
Timeframe: 60 Minutes prior to transfusion to 48 hours after transfusion
Infants Developing TR-NEC
Timeframe: 60 Minutes prior to transfusion to 48 hours after transfusion
Inhibition of NO-Mediated Vasodilation
Timeframe: 60 Minutes prior to transfusion to 48 hours after transfusion
Metabolic Changes of Red Blood Cells
Timeframe: 60 Minutes prior to transfusion to 48 hours after transfusion
Mesenteric Tissue Oxygenation During the NEC Window Period
Timeframe: 28 to 34 Weeks Post Menstrual Age
Immune Cell Function
Timeframe: Up to 90 days of age
Microbial Changes
Timeframe: Up to 90 days of age
Serum Cytokine Levels
Timeframe: Up to 90 days of age