CompletedNot Applicable

Activating and Identifying Neural Responses to Social Rejection: a Combined tDCS and fMRI Study

United States19 participantsStarted 2018-02-14

Plain-language summary

This research study identifies neural pathways regulating negative moods during rejection by combining transcranial direct current stimulation (tDCS) and fMRI in a sample of healthy controls.

Who can participate

Age range18 Years – 25 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Healthy males or females between 18 and 25 years old
✓. No diagnosis on Axis I by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV. No current, or within the past 5 years.
✓. Not currently in a romantic relationship
✓. Ability to understand and follow instructions and oriented to name, time, and place.
✓. No additional neurologic or psychiatric disorders
✓. No current use of psychotropic drugs or during past 3 months (except marijuana and alcohol)
✓. No current use of marijuana or during past 3 weeks
✓. Not currently abusing alcohol

Exclusion criteria

✕. Left-handed or ambidextrous
✕. Metallic dental implants
✕. Metallic objects in the brain/skull
✕. Medical device implants
✕. Implanted electronic devices
✕. History of seizures
✕. History of strokes
✕. Unexplained loss of consciousness

What they're measuring

Blood Oxygen Level Dependent (BOLD) Signal Changes (in Arbitrary Units)

Timeframe: 1-3 weeks

Change in Positive and Negative Affect Scale (During fMRI)

Timeframe: 1-3 weeks

Change in the Single-item Self-Esteem Scale (During fMRI)

Timeframe: 1-3 weeks

Change in Desire for Social Interaction Scale (During fMRI)

Timeframe: 1-3 weeks

Trial details

NCT IDNCT02739789

SponsorStony Brook University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-10-16

Results submitted2020-05-11

View on ClinicalTrials.gov More Healthy trials

Who can participate

Age range18 Years – 25 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Healthy males or females between 18 and 25 years old
✓. No diagnosis on Axis I by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV. No current, or within the past 5 years.
✓. Not currently in a romantic relationship
✓. Ability to understand and follow instructions and oriented to name, time, and place.
✓. No additional neurologic or psychiatric disorders
✓. No current use of psychotropic drugs or during past 3 months (except marijuana and alcohol)
✓. No current use of marijuana or during past 3 weeks
✓. Not currently abusing alcohol

Exclusion criteria

✕. Left-handed or ambidextrous
✕. Metallic dental implants
✕. Metallic objects in the brain/skull
✕. Medical device implants
✕. Implanted electronic devices
✕. History of seizures
✕. History of strokes
✕. Unexplained loss of consciousness

What they're measuring

Blood Oxygen Level Dependent (BOLD) Signal Changes (in Arbitrary Units)

Timeframe: 1-3 weeks

Change in Positive and Negative Affect Scale (During fMRI)

Timeframe: 1-3 weeks

Change in the Single-item Self-Esteem Scale (During fMRI)

Timeframe: 1-3 weeks

Change in Desire for Social Interaction Scale (During fMRI)

Timeframe: 1-3 weeks