Activating and Identifying Neural Responses to Social Rejection: a Combined tDCS and fMRI Study (NCT02739789) | Clinical Trial Compass
CompletedNot Applicable
Activating and Identifying Neural Responses to Social Rejection: a Combined tDCS and fMRI Study
United States19 participantsStarted 2018-02-14
Plain-language summary
This research study identifies neural pathways regulating negative moods during rejection by combining transcranial direct current stimulation (tDCS) and fMRI in a sample of healthy controls.
Who can participate
Age range
18 Years – 25 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Healthy males or females between 18 and 25 years old
. No diagnosis on Axis I by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV. No current, or within the past 5 years.
. Not currently in a romantic relationship
. Ability to understand and follow instructions and oriented to name, time, and place.
. No additional neurologic or psychiatric disorders
. No current use of psychotropic drugs or during past 3 months (except marijuana and alcohol)
. No current use of marijuana or during past 3 weeks
. Not currently abusing alcohol
Exclusion criteria
. Left-handed or ambidextrous
. Metallic dental implants
. Metallic objects in the brain/skull
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Blood Oxygen Level Dependent (BOLD) Signal Changes (in Arbitrary Units)
Timeframe: 1-3 weeks
2
Change in Positive and Negative Affect Scale (During fMRI)
Timeframe: 1-3 weeks
3
Change in the Single-item Self-Esteem Scale (During fMRI)
Timeframe: 1-3 weeks
4
Change in Desire for Social Interaction Scale (During fMRI)