CompletedPhase 4

MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty

United States130 participantsStarted 2016-04

Plain-language summary

Compare the outcome following manipulation under anesthesia for stiffness in a randomized controlled fashion with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Outcomes will include pain, range of motion, as well as subjective outcome scores.

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion criteria

✓. Subjects who have received a primary unilateral TKA for a diagnosis of osteoarthritis.
✓. MUA's scheduled between 6-10 weeks postoperatively

Exclusion criteria

✕. Intolerance to NSAIDs
✕. Renal dysfunction
✕. Age \< 18 or \> 90 years
✕. Primary diagnosis of rheumatoid arthritis
✕. Patients with a Glomerular Filtration Rate (GFR) \<60 as the cut off for Chronic Kidney Disease (CKD) (stage 3 CKD)

What they're measuring

Knee Range of Motion After Manipulation Under Anesthesia

Timeframe: 6 weeks after manipulation

Knee Range of Motion After Manipulation Under Anesthesia

Timeframe: 1 year from the date of the manipulation

Trial details

NCT IDNCT02739035

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12

Results submitted2023-09-28

View on ClinicalTrials.gov More Stiffness Following Total Knee Arthroplasty trials