Xingnaojing for Moderate-to-severe Acute Ischemic Stroke (XMAS)
China720 participantsStarted 2016-03
Plain-language summary
The main purpose of this trial is to determine whether Xingnaojing, intravenously administered within 24 hours of symptom onset, improves the 3-month outcome in participants with acute ischemic stroke.
Who can participate
Age range
35 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Acute ischemic stroke within 24 hours of symptom onset.
* National Institutes of Health Stroke Scale score ≥ 5 and ≤ 20.
* Age ≥ 35 and ≤ 80 years.
* Patient or legally authorized representative has signed informed consent.
Exclusion Criteria:
* Planned or already received endovascular treatment.
* Suspected secondary stroke caused by tumor, brain trauma, or hematologic diseases.
* Already dependent in activities of daily living before the present acute stroke (defined as modified Rankin Scare score ≥2 ).
* Other conditions that lead to motor dysfunction (e.g. severe osteoarthrosis, rheumatoid arthritis).
* Significant renal or hepatic insufficiency (defined as a serum creatinine concentration, alanine aminotransferase, or aspartate aminotransferase value that is twice greater than the upper limit of normal).
* Life expectancy of 90 days or less due to other life threatening illness (e.g. advanced cancer).
* Other conditions that render outcomes or follow-up unlikely to be assessed..
* Known to be pregnant or breastfeeding.
* Currently receiving an investigational drug.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.