Examination of Glutamate and mGluR5 in Psychiatric Disorders (NCT02727972) | Clinical Trial Compass
CompletedNot Applicable
Examination of Glutamate and mGluR5 in Psychiatric Disorders
United States180 participantsStarted 2012-02-21
Plain-language summary
This research study is designed to look at the involvement of the glutamate system in depression. Each subject will undergo a screening appointment to determine study eligibility. Thereafter, the study will take 2 or 3 visits depending on schedule availability and will consist of one MRI scan, and PET scan. Subjects will also participate in cognitive testing. Depending on camera time, staff availability and subject schedule, total study participation may last 1-2 months.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
General inclusion criteria:
* Subjects will be between the ages of 18-70 years old
* English speaking
* No other DSM-5 diagnosis present, besides required as below
Inclusion criteria for acute depressed subjects:
* Clinical diagnosis of a current depressive episode
* Medication-free for at least 2 weeks or medicated with a permissible medication
Inclusion criteria for PTSD subjects:
* Clinical diagnosis of current PTSD as per DSM-5
* Medication free for at least 2 weeks or medicated with a permissible medication
Inclusion criteria for healthy controls:
* No current, or history of, any DSM-5 diagnosis
Exclusion Criteria:
* Have a current or past significant medical, neurological or metabolic disorder or head injury that lead to significant long term decline in cognitive abilities as seen by decline in grades or work performance
* Have significant medical illness such that would contraindicate study participation based on above criteria and PI/MD history review
* Have active, significant suicidal ideation
* Have implanted metallic devices or any MR contraindications
* Are women who are pregnant or breastfeeding
* Met DSM-5 criteria for mild substance use disorder (except nicotine and marijuana) within the past 6 months or met DSM-5 criteria for moderate to severe substance use disorder (except nicotine and marijuana) within the past year
* Have history of prior radiation exposure for research purposes within the past year such that participation in…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Evidence of glutamate availability (mGluR5) in psychiatric disorders confirmed by MRI and PET data.
Timeframe: Through study completion date, an average of 4 years.