CompletedNot Applicable

Lifestyle Enriching Activities for Research in Neuroscience Intervention Trial: LEARNit Study

United States66 participantsStarted 2016-08-21

Plain-language summary

The purpose of this study is to examine the effects of modifiable lifestyle factors including exercise and healthy living on brain health. The investigators will compare 2 types of interventions, moderate aerobic walking vs. healthy living education, over 6 months to evaluate changes in brain health, cognition, and physical function in older adults with cognitive concerns.

Who can participate

Age range55 Years – 80 Years

SexALL

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Inclusion criteria

✓. Male or female
✓. English-speaking
✓. 55-80 years old
✓. Exhibits sedentary behavior
✓. Objective cognitive impairment
✓. Mini-Mental State Exam score \> 26
✓. Perform at least 1 standard deviations below normative values on cognitive tests
✓. Absence of dementia

Exclusion criteria

✕. Baseline dementia
✕. History of a neurological disorder
✕. Current psychiatric illness
✕. Head trauma with a loss of consciousness \> 10 minutes
✕. Severe sensory deficits
✕. Substance abuse
✕. Depression (GDS \< 8 of 15)
✕. Inability to perform intervention (e.g., inability to walk without assistance)

What they're measuring

Functional Magnetic Resonance Imaging (fMRI) Brain Scan as a Measure of Brain Function

Timeframe: Baseline and Follow-up at 6 months

Mnemonic Similarity Test as a Measure of Memory (Cognition)

Timeframe: Baseline and Follow-up at 6 months

Trial details

NCT IDNCT02726906

SponsorUniversity of Southern California

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-07-13

Results submitted2024-06-24

View on ClinicalTrials.gov More Aging trials