CompletedNot Applicable

Symptom Based Treatment Affects Brain Plasticity - the Role of Verbal Auditory Hallucinations

Germany81 participantsStarted 2016-07

Plain-language summary

The aim of the study is the examination of brain plasticity on verbal auditory hallucinations (AVH) after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback. During the training of fMRI neurofeedback subjects are trained to regulate consciously the connectivity of areas which are associated with hallucinations.The aim is to improve perceived hallucinations' intensity in everyday life of the patients as well as investigating the impact of neurofeedback on resting-state networks in the brain. As control groups, control subjects without AVH and participants with AVH, but no psychiatric diagnosis will be included.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Schizophrenia according to ICD-10 (F2x) with verbal hallucinations or only verbal hallucinations (no psychiatric diagnosis) or healthy subjects without verbal hallucinations * Fluent German language skills Exclusion Criteria: * addiction * severe affective disorder * any contraindication to MRI examination or claustrophobia * pregnant or lactating women * traumatic brain lesions * acute physical or neurological impairments * acute suicidal tendency * Lack of informed consent

What they're measuring

change in self-control over neuronal connectivity

Timeframe: 1 week

Trial details

NCT IDNCT02722915

SponsorRWTH Aachen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12

View on ClinicalTrials.gov More Hallucinations, Verbal Auditory trials