the Efficiency of Endoscopic Treatment for Recurrent Small Intestinal Bleeding Due to Gastrointestinal Vascular Malformation

Inclusion Criteria: The patients should sign informed consent and be informed of the specific trial plan; * The patients should have the China nationality; * The patients should be aged from 18 to 70 years old, male or female; * The intestinal vascular lesions should be found by capsule endoscopy, and / or balloon assisted enteroscopy; OR the patients should present with persistent and recurrent bleeding, while the bleeding lesions are unable to be located by all these examinations mention above; * The patients should present with persistent and recurrent bleeding (\>=2 times for one year); * Hb levels should decreased 10% lower than baseline. * The patient is willing to comply with the instructions and have the ability to complete the study of research program. Exclusion Criteria: patients associated with varicosity due to cirrhosis of the liver; Or patients with uncontrolled hypertension, hyperglycemia, or other severe diseases; * patients with a history of severe peripheral neuropathy, seizures, rheumatoid immune disease, or thromboembolic disease; * patients with indications which should constantly use non-steroidal anti-inflammatory drugs, anticoagulants and anti-platelet or acetyl salicylic acid preparation, ginkgo, Echinacea, Chinese herbal medicine composition, other anti-angiogenesis drugs; * patients with malignant or severe heart disease (uncontrolled angina and/or myocardial infarction, congestive heart failure within 3 months before recruiting, etc.), lung d…