WithdrawnNot Applicable

Changes in Ventilation Inhomogeneity and Respiratory Function Following Elective Caesarean Section Under Regional Anaesthesia

Stopped: Ethical approval not obtained yet as questioning the danger of providing 100% oxygen to parturients.

Switzerland0Started 2016-05

Plain-language summary

Pregnancy is associated with physiological changes affecting the cardiorespiratory system as a consequence of an increase in both cardiac output and intra-abdominal pressure. The aim of this prospective observational study is to examine the perioperative changes in ventilation inhomogeneity and respiratory function measured by the non-invasive nitrogen multiple breath washout and forced oscillation techniques.

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Written informed consent * Pregnant woman in the third trimester (37-40 weeks gestational age) * Scheduled for elective caesarean section under regional (spinal or combined spinal-epidural) anaesthesia Exclusion Criteria: * Pregnant women outside 37-40 weeks gestational age * Non-singleton pregnancy * Previous history of ≥2 caesarean sections * History or clinical signs of cardiopulmonary disease in the last 12 months (chronic hypertension, gestational hypertension, preeclampsia, asthma, acute or chronic bronchitis, others) * Positive current smoking status * Pre-pregnant body mass index (BMI) \>30 kg/m2 (based on booking records) * Respiratory infection \<2 weeks prior to surgery * Inability to perform the respiratory function tests

What they're measuring

Perioperative changes in ventilation inhomogeneity (LCI) following delivery by caesarean section

Timeframe: 1-3 days prior to caesarean section until 5 days postoperative

Trial details

NCT IDNCT02714556

SponsorWalid HABRE

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-10