UnknownNot Applicable

Impact of Helminth Infections During Pregnancy on Humoral Vaccine Immunogenicity in Infants

323 participantsStarted 2014-02

Plain-language summary

Helminth infection is associated with low vaccine immunogenicity. Pregnant women are particularly sensitive to helminth infection. Since most vaccines are given shortly after birth, an effect of parasites on infant immunogenicity is of particular concern. Therefore, within this study the investigators aim to investigate if maternal infection influences vaccine immunogenicity in the newborn.

Who can participate

Age range18 Years

SexFEMALE

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Inclusion Criteria: * Signed informed consent form (ICF) by the participant aged 18 years or older or by a legal major representative and the participant * Willingness to deliver in one of the two maternities in the study area * Willingness and ability to comply with study protocol for the duration of the trial * Willingness to give blood for the examinations and to provide samples for helminth assessment (stool, urine, blood) Exclusion Criteria: * Known chronic diseases (diabetes, TB, HIV, HCV or HBV infection); these will be assessed on a regular basis at given examinations during pregnancy * Withdrawal of consent * Poor general health (including a hemoglobin level out of local reference range) * Signs of symptoms of helminth infection which needs immediate treatment of the mother * Planned migration from the area

What they're measuring

Difference in Immunoglobulin G (IgG) concentration against EPI vaccine Ags of infants born to helminth infected mothers and non infected mothers at the age of nine months and 12 months

Timeframe: 12 months of observation

Trial details

NCT IDNCT02714348

SponsorCentre de Recherche Médicale de Lambaréné

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-09