CompletedNot Applicable

The Effect of Anesthetics on Oxidative Stress and Apoptosis Status in Children

China47 participantsStarted 2015-09

Plain-language summary

The purpose of this study is to determine whether Propofol and Sevoflurane affect the oxidative stress and apoptosis status in children undergoing hypospadias repair surgery.

Who can participate

Age range1 Year – 3 Years

SexMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * American Society of Anesthesiology (ASA) I-II, undergoing selective surgery for hypospadias repair. Exclusion Criteria: * a history of developmental delay or mental retardation, which could make observational pain intensity assessment outside the norm; * a history of central nervous system diseases; * a known or suspected coagulopathy; * a known allergy to any of the study drugs; * abnormalities of the sacrum and any signs of infection at the site of the proposed caudal block.

What they're measuring

the change of blood glutathione peroxidase(GPx) level in perioperative period

Timeframe: immediately after anesthetic induction, 2h and 3 days after operation

the change of blood-separated erythrocytes superoxide dismutase (SOD) activities in perioperative period

Timeframe: immediately after anesthetic induction, 2h and 3 days after operation

the change of blood-separated erythrocytes catalase (CAT) activities in perioperative period

Timeframe: immediately after anesthetic induction, 2h and 3 days after operation

the change of blood-separated lymphocytes caspase-3 mRNA level in perioperative period

Timeframe: immediately after anesthetic induction, 2h and 3 days after operation

Trial details

NCT IDNCT02711280

SponsorFirst Affiliated Hospital, Sun Yat-Sen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-03

View on ClinicalTrials.gov More Anesthesia, General trials