CompletedNot Applicable

Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium

42 participantsStarted 2015-06

Plain-language summary

This is a prospective self controlled clinical trial. Women with clomiphene Citrate failure, and thin endometrium were recruited (N = 42). In their 6th (Clomiphene citrate only) cycle, women continued on Clomiphene citrate 100 mg/ day for 5 days, and had sonographic measurement of their endometrial thickness , and Doppler evaluation of their uterine arteries on the day of HCG administration. In 7th cycle, women (N = 36) were given usual dose of Clomiphene citrate supplemented with sildenafil vagina gel (5 gm, containing 50 mg sildenafil) twice daily from cycle day 8 till the day of HCG injection. Endometrial thickness and uterine artery Doppler were measured on the day of HCG administration.

Who can participate

Age range20 Years – 40 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women with clomiphene citrate failure (defined as at least prior 5 ovulatory cycles with clomiphene citrate, with no conception), * persistently thin endometrium (less than 8 mm in at least 3 cycles). * normal baseline FSH, LH, and free testosterone levels, patent tubes on hysterosalpingography, and normal male semen analysis Exclusion Criteria: * Women with major medical problems, * male factor infertility, * endocrine abnormalities such as hyperprolactinemia or abnormal thyroid functions, * prior ovarian or adnexal surgery, or organic pelvic pathology

What they're measuring

Endometrial Thickness

Timeframe: Day of HCG administration

Trial details

NCT IDNCT02710981

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-01

Results submitted2020-04-12

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