SmartMouth Advanced Clinical Formula Clinical Research Design Protocol

Inclusion Criteria: * Subjects between the ages of 18 to 80 * Subjects with a diagnosis of gingivitis or chronic periodontitis * Entry levels of gingival inflammation and plaque accumulation will be present (mean Gingival Index ≥ 0.4 and Plaque Index ≥ 1.0) * Subjects that are in good medical health at time of the study * At least 20 permanent natural teeth Exclusion Criteria: * Use of local or systemic antibiotics during the course of the study * Subjects that are pregnant or nursing mothers * Subjects undergoing orthodontic therapy * Subjects wearing removable prostheses * Subjects taking medication which is altering the gingiva or causing inflammation * Gingival overgrowth * History of sensitivity or suspected allergies following the use of oral hygiene products * Subjects taking anti-inflammatory or anticoagulant medications that would alter the gingiva and promote bleeding * Subjects that require antibiotic prophylaxis prior to dental treatment * Subjects that have acute dental problems requiring immediate treatment