CompletedNot Applicable

Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults

United States129 participantsStarted 2016-05-03

Plain-language summary

The overall objectives are to: 1. Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the whole-body, tissue, and cellular levels. 2. Systematically compare different HIIT regimens to help identify effective "doses" of HIIT that may be optimal for improving metabolic health in obese adults. 3. Assess the ability/willingness of obese subjects to adhere to a long-term HIIT program. Findings from these studies will greatly expand knowledge about the effects of HIIT on metabolic health, and will provide valuable information for development of programs aimed at maximizing key metabolic benefits of exercise.

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: 18-40 * Body Mass Index: 30-40 kg/m2 * Waist circumference: 88-98cm for women and 100-110cm for men * Glucose intolerant (i.e., 2h glucose concentration during a screening oral glucose tolerance test (OGTT)= 140-199mg/dl * No regularly planned exercise/physical activity * Women must have regularly occurring menses and must be premenopausal Exclusion Criteria: * EKG abnormalities as assessed by the cardiologist on the research team * Evidence/history of cardiovascular or metabolic disease * Medications known to affect lipid or glucose metabolism * Pregnant or lactating * Tobacco or e-cigarette use

What they're measuring

Insulin Sensitivity

Timeframe: Change from Baseline at 3 months

Trial details

NCT IDNCT02706093

SponsorUniversity of Michigan

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-05-04

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