Neurobiology of Posttraumatic Stress Disorder Dysfunction and Recovery Following Cognitive Proces… (NCT02695953) | Clinical Trial Compass
By InvitationNot Applicable
Neurobiology of Posttraumatic Stress Disorder Dysfunction and Recovery Following Cognitive Processing Therapy
United States130 participantsStarted 2016-03
Plain-language summary
Posttraumatic stress disorder (PTSD) is a significant personal and societal burden. The purpose of this study is to examine genetic, epigenetic, behavioral, and brain activity changes related to PTSD dysfunction and recovery before and after treatment with Cognitive Processing Therapy.
Who can participate
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* PTSD diagnosis, as measured by the Clinician Administered PTSD Scale for DSM-5
* history of chronic childhood trauma due to relational abuse
* Ability to understand and sign informed consent
* Enrollment in CPT program at McLean Hospital
* Both genders, all ethnic backgrounds, age between 18 and 55
* Fluent English speakers
* Normal or Corrected Vision
Exclusion Criteria:
* History or current schizophrenia spectrum disorder or other psychotic disorders
* History or current bipolar or other related disorders
* Alcohol and/or substance use disorder within the past month
* Metal implants
* Medical or neurological illness (e.g., seizures, head injury in which they experienced a loss of consciousness)
* Positive pregnancy test
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Potential Change in Evidence of PTSD symptoms with neuroimaging
Timeframe: Within 30 days before and again within 30 days after Cognitive Processing Therapy Treatment.