MicroRNA Mediates Volatile Anesthetics Preconditioning Induced Artery Protection

Inclusion Criteria: * age \>18 years * written informed consent; * scheduled procedures; * planned isolated OPCABG(multiple bypass are allowed; planned combined intervention such as CABG plus valve surgery are not allowed); * ejection fraction\> 50%; * NYHA class Ⅱ\~Ⅲ; * serum creatinine \<150μmol / l; * preoperative platelet content \> 100 × 109 / l; * preoperative hemoglobin\> 120 g / l Exclusion Criteria: * pregnancy; * planned valve surgery or surgery on the aorta; * left main coronary artery stenosis\> 75%; * echocardiographic examination revealed moderate to severe mitral, tricuspid, or aortic regurgitation or stenosis; * unstable or ongoing angina; * recent (\< 1 month) or ongoing acute myocardial infarction; * use of sulfonylurea, theophylline or allopurinol; * previous unusual response to an anesthetic agent; * inclusion in other randomised controlled studies in the previous 30 days; (10)any general anesthesia performed in the previous 30 days; * emergency operation (not scheduled); * kidney or liver transplant in medical history, liver cirrhosis (Child B or C); * chronic respiratory disease (such as chronic obstructive pulmonary emphysema)