UnknownPhase 4

MicroRNA Mediates Volatile Anesthetics Preconditioning Induced Artery Protection

China60 participantsStarted 2016-01

Plain-language summary

It has been reported that volatile anesthetics preconditioning mediates protection of organ via microRNA. We want to study on the effects of isoflurane preconditioning on expression of microRNA and mRNA in the specimens of internal mammary artery and ascending aorta.

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age \>18 years * written informed consent; * scheduled procedures; * planned isolated OPCABG(multiple bypass are allowed; planned combined intervention such as CABG plus valve surgery are not allowed); * ejection fraction\> 50%; * NYHA class Ⅱ\~Ⅲ; * serum creatinine \<150μmol / l; * preoperative platelet content \> 100 × 109 / l; * preoperative hemoglobin\> 120 g / l Exclusion Criteria: * pregnancy; * planned valve surgery or surgery on the aorta; * left main coronary artery stenosis\> 75%; * echocardiographic examination revealed moderate to severe mitral, tricuspid, or aortic regurgitation or stenosis; * unstable or ongoing angina; * recent (\< 1 month) or ongoing acute myocardial infarction; * use of sulfonylurea, theophylline or allopurinol; * previous unusual response to an anesthetic agent; * inclusion in other randomised controlled studies in the previous 30 days; (10)any general anesthesia performed in the previous 30 days; * emergency operation (not scheduled); * kidney or liver transplant in medical history, liver cirrhosis (Child B or C); * chronic respiratory disease (such as chronic obstructive pulmonary emphysema)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

microRNA

Timeframe: 1h after isoflurane treatment(specimens of internal mammary artery and ascending aorta stump are saved)

NOS3 mRNA,mRNA levels of adhesion molecule selectin -E,vascular cell adhesion molecule -1,vascular endothelial growth factor -1,intercellular adhesion molecule,RhoA and ROK

Timeframe: 1h after isoflurane treatment(specimens of internal mammary artery and ascending aorta stump are saved)

phosphatidylinositol-3-kinase,alanine aminotransferase,endothelial nitric oxide synthase

Timeframe: 1h after isoflurane treatment(specimens of internal mammary artery and ascending aorta stump are saved)

Trial details

NCT IDNCT02678650

SponsorLiang Zhang

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-01

Contact for this trial

Jun Ma, MD

010-64456329 majun7689@163.com

View on ClinicalTrials.gov More Coronary Artery Bypass Graft Triple Vessel trials

Who can participate

Age range

18 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

microRNA

Timeframe: 1h after isoflurane treatment(specimens of internal mammary artery and ascending aorta stump are saved)

NOS3 mRNA,mRNA levels of adhesion molecule selectin -E,vascular cell adhesion molecule -1,vascular endothelial growth factor -1,intercellular adhesion molecule,RhoA and ROK

Timeframe: 1h after isoflurane treatment(specimens of internal mammary artery and ascending aorta stump are saved)

phosphatidylinositol-3-kinase,alanine aminotransferase,endothelial nitric oxide synthase

Timeframe: 1h after isoflurane treatment(specimens of internal mammary artery and ascending aorta stump are saved)