Visualising c-MET and Activated Neutrophils in Lung Cancer

INCLUSION CRITERIA FOR COHORT 1 • Patients undergoing cardiothoracic surgery for resection of lung cancer INCLUSION CRITERIA FOR COHORT 2 • Patients with inoperable stage 3 or 4 lung cancer INCLUSION CRITERIA FOR BOTH COHORTS * ≥ 16 years * Provision of informed consent from the patient prior to any study related procedures. * Normal electrocardiogram (ECG) * Forced Expiratory Volume (FEV1) \>1L * Thoracic CT scan taken in the last 20 weeks * Attending consultant permission for bronchoscopy * Readily accessible target areas with bronchoscopy and FE EXCLUSION CRITERIA * Refusal for participation by attending consultant * Unsuitable for bronchoscopy * Any history of anaphylaxis * Significant coagulopathy, which causes bronchoscopy to be unsuitable, as determined by clinical co-investigator or the participant's attending consultant, using information which is routinely available * Myocardial infarction in the preceding four weeks * Women who are pregnant or are breastfeeding * Receiving drugs that cause increased autofluorescence in the lung, specifically amiodorane and methotrexate * Oxygen saturation \<92% breathing room air * Platelet count \< 50 x 109/L * Bleeding diathesis