Muscular Biomarkers in Amyotrophic Lateral Sclerosis
France37 participantsStarted 2016-03-29
Plain-language summary
The first objective is to find some biomarkers, or a profile of biomarkers of ALS to help to diagnosis. The second objective is to better understand the pathogenesis of this disease by the exploration of muscle, blood and satellite cells metabolomes and transcriptomes.
Who can participate
Age range18 Years – 75 Years
SexALL
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Case group selection criteria:
Inclusion Criteria:
* Age ≥ 18 years and ≥ 75 years
* ALS according to the El Escorial criteria
* Patients affiliated to social security scheme
* Informed consent signed by the patient
Exclusion Criteria:
* Pregnant or breastfeeding women
* Contraindication to biopsy
* Contraindication to local anesthesia
* Treatment with oral or injectable anticoagulants, antiplatelet (except aspirin)
* Unbalanced Diabetes
* Systemic corticosteroid treatment
* Treatment against cramps or twitching may affect muscle metabolism
Control group selection criteria:
Inclusion Criteria:
* Age ≥ 18 years and ≥ 75 years
* No neuronal disease
* Patients affiliated to social security scheme
* Informed consent signed by the patient
Exclusion Criteria:
* Pregnant or breastfeeding women
* Contraindication to biopsy
* Treatment with oral or injectable anticoagulants, antiplatelet (except aspirin)
* Unbalanced Diabetes
* Systemic corticosteroid treatment
* Treatment against cramps or twitching may affect muscle metabolism