This pilot early phase I trial studies how adavosertib affects the tumor deoxyribonucleic acid (DNA) of patients undergoing surgery for high grade (fast growing or aggressive) ovarian, fallopian tube, or primary peritoneal cancer that has spread to other places in the body (advanced). Certain characteristics in the DNA of these patients may affect how well they respond to treatment. Learning how adavosertib affects DNA in tumor cells may help doctors plan effective treatment.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Change in level of deoxyribonucleic acid (DNA) copy number in p53-related pathways
Timeframe: Baseline up to 28 days
Change in level of mutation in p53-related pathways
Timeframe: Baseline up to 28 days
Change in level of ribonucleic acid (RNA) expression in p53-related pathways
Timeframe: Baseline up to 28 days
Change in level of protein expression in p53-related pathways
Timeframe: Baseline up to 28 days