CompletedNot Applicable

L-menthol as a Topical Counter-irritant to TRPA1-induced Neurogenic Inflammation and Pain

14 participantsStarted 2014-10

Plain-language summary

The aim of this study is to quantitatively characterize the effects of L-menthol as a topical counter-irritant on cutaneous pain and hyperalgesia provoked by topical application of the TRPA1-agonist trans-cinnamaldehyde (CA) in healthy human volunteers.

Who can participate

Age range18 Years – 50 Years

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Inclusion Criteria: * 18 healthy men and women aged 18-50 years willing to abstain from alcohol, nicotine, caffeine and pain medication 24 hours before experimental sessions Exclusion Criteria: * Pregnancy * Skin disorders (e.g. contact eczema) * Chronic pain conditions * Drug addiction defined as the use of cannabis, opioids or other drugs * Previous neurologic, musculoskeletal or mental illnesses * Lack of ability to cooperate

What they're measuring

Spontaneous pain intensity [self-reported on a visual analog scale]

Timeframe: 0-20 minutes with a sampling frequency of 1/1 min

Trial details

NCT IDNCT02653703

SponsorAalborg University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-12

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