CompletedNot Applicable

Autologous Cartilage Implantation vs Arthroscopic Debridement

Norway28 participantsStarted 2016-04

Plain-language summary

82 patients aged 18-49 years with an isolated focal cartilage defect in the knee will be randomized to either receive autologous cartilage implantation or arthroscopic debridement. Both groups will then undergo a systematic physiotherapy training regime for 6-9 months. The Groups will then be compared for results, after 3, 6, 12 and 24 months, by using validated patient reported outcome scores (Lysholm, KOOS, Tegner) and EQ5D (European Quality of Life 5 dimensions) as well as clinical examination and radiological findings at 2 years (MRI).

Who can participate

Age range18 Years – 49 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Single symptomatic lesion of the trochlea, medial or lateral femoral condyle of the knee larger than 2 cm2. * Cartilage lesion ICRS grade 3 or 4. * More than 50 % of the menisci intact. * Ligamentous stable knee * Lysholm Score \< 75 * Acceptable range of motion (5-105 degrees) Exclusion Criteria: * Osteoarthritis * Malalignment \> 5 degrees measured on HKA (hip-knee-ankle) radiographs * Systemic arthritis * Previous cartilage surgery * Obesity BMI \> 30 * Serious drig or alcohol abuse * Inability to answer questionnaires or partake in rehabilitation * Comorbidity that may influence surgery or rehabilitation

What they're measuring

The Knee Injury and Osteoarthritis Outcome Score (KOOS) Quality of Life

Timeframe: up to 24 months

Trial details

NCT IDNCT02636881

SponsorUniversity Hospital, Akershus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-09

View on ClinicalTrials.gov More Knee Injury trials