CompletedNot Applicable

Multimodal Assessment of Sensory Processing and Brain Features in Patients With Chronic Orofacial Pain

United States39 participantsStarted 2016-01

Plain-language summary

This proposal will investigate pain modulatory mechanisms and brain functional and structural characteristics using multiple MRI modalities in persistent dentoalveolar pain disorder (PDAP) patients with and without temporomandibular disorders (TMD). All measures from patients will be compared to painfree controls.

Who can participate

Age range18 Years – 65 Years

SexFEMALE

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Inclusion criteria

✓. Age- and handedness-matched painfree controls using frequency matching to maintain similar group averages:
✓. PDAP only:
✓. PDAP with TMD:

Exclusion criteria

✕. Chronic widespread pain
✕. Current use of opioids or other pain medications (e.g., ibuprofen/acetaminophen) that cannot be stopped \<3 days prior to testing
✕. Conditions/diseases associated with altered pain perception: neurological (e.g., multiple sclerosis, trigeminal neuralgia) psychiatric disorders, diabetes, neoplasm and cardiovascular disorders
✕. Injury to hands
✕. Substance abuse
✕. MRI contraindications including pregnancy

What they're measuring

Pressure pain threshold change before and during conditioned pain modulation

Timeframe: Baseline

Trial details

NCT IDNCT02630771

SponsorUniversity of Minnesota

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-03

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