CompletedNot Applicable

Reliability of Pupil Response to Acute Pain

United States20 participantsStarted 2015-08-04

Plain-language summary

The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.

Who can participate

Age range18 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult (18-70) * Pain from hip or knee arthritis of moderate intensity * American Society of Anesthesiologists physical status 1-3 Exclusion Criteria: * Inability to complete study questionnaires * Pregnancy * Litigation or workers compensation related to hip or knee pain * Taking \> 50 mg morphine equivalents/day * History of Raynaud's disease of the feet * Psychotic disorder or a recent psychiatric hospitalization * History of eye surgery or topical eye medications that would would directly affect pupil diameter

What they're measuring

Percentage of change in pupil diameter

Timeframe: 8 weeks

Change from Baseline Verbal Pain Scores

Timeframe: 8 weeks

Trial details

NCT IDNCT02628314

SponsorWake Forest University Health Sciences

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-16

View on ClinicalTrials.gov More Pain trials