CompletedNot Applicable

Circulating BDNF in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training

Canada200 participantsStarted 2016-02-16

Plain-language summary

The main purpose of this project is to determine the impact of atrial fibrillation interventions (catheter ablation and exercise training) on circulating BDNF concentrations in patients with atrial fibrillation. It also seeks to determine if there is a relation between circulating BDNF concentrations and mental health (depression severity, quality of life and symptoms) among those undergoing interventions for atrial fibrillation catheter ablation or exercise training.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Subjects must be either currently enrolled in the OPPORTUNITY trial (NCT02602457) or have paroxysmal atrial fibrillation and be scheduled to undergo catheter ablation (for the first time) through the electrophysiology clinic at the University of Ottawa Heart Institute.
✓. Subjects must be willing and able to provide a blood sample.
✓. Subjects must be willing and able to provide informed consent.

Exclusion criteria

✕. Subject is not either currently enrolled in the OPPORTUNITY trial (NCT02602457) or scheduled to undergo catheter ablation (for the first time) through the electrophysiology clinic at the University of Ottawa Heart Institute for paroxysmal atrial fibrillation.
✕. Subjects with congestive heart failure with heart failure admission in the past 3 months.
✕. Subjects with a cerebrovascular accident in the past 3 months
✕. Subjects with severe dementia.
✕. Subjects with a history of severe psychiatric illness (e.g., schizoaffective disorder, bipolar disorder, or schizophrenia).
✕. Subjects with an active infection or inflammatory condition.
✕. Subjects who are pregnant, lactating or planning to become pregnant during the study period.
✕. Subject is unable to read or understand English or French.

What they're measuring

Changes in circulating BDNF concentrations measured by blood samples collected from subjects with atrial fibrillation

Timeframe: approximately 3 months post catheter ablation or following the 12 week exercise training intervention period

Trial details

NCT IDNCT02627183

SponsorOttawa Heart Institute Research Corporation

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06-13

View on ClinicalTrials.gov More Atrial Fibrillation trials