TerminatedPhase 4

Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis

Stopped: Slow Accrual

United States3 participantsStarted 2016-04-27

Plain-language summary

The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Outpatients with MPE undergoing IPC placement
✓. Age 18 or older
✓. Sufficient mental capacity to answer SF-6D and Borg score questions.

Exclusion criteria

✕. Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax)
✕. Inability or unwillingness to give informed consent
✕. Inability to perform phone call and clinical follow-up at MDACC
✕. Previous intrapleural therapy for MPE on the same side
✕. Chylous effusions associated with malignant disease
✕. ECOG of 4 and life expectancy \</= 2 weeks
✕. Doxycycline allergy
✕. Contraindication to placement of an IPC (e.g., uncorrected coagulopathy)

What they're measuring

The Primary Outcomes of Interest Will be Time to Catheter Removal.

Timeframe: 1 month

Trial details

NCT IDNCT02623959

SponsorM.D. Anderson Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-05-23

Results submitted2019-04-16

View on ClinicalTrials.gov More Advanced Cancers trials