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Cholangiography Using Carbon Dioxide Versus Iodinated Contrast in ERCP

United States40 participantsStarted 2016-02

Plain-language summary

Carbon dioxide (CO2) gas is widely used for luminal insufflation during endoscopic retrograde cholangiopancreatography (ERCP) of the biliary tract. While frequently observed during routine ERCP, there are few data on the topic of "air" or "CO2" cholangiography. Our primary aim is to compare radiographic cholangiograms in patients with biliary tract disease (from stones or strictures) during ERCP obtained by using carbon dioxide as the contrast medium vs. conventional iodinated contrast.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients 18 years of age or older * Patients with choledocholithiasis, benign biliary strictures, malignant biliary strictures * Biliary pathology suggested or confirmed by imaging with abdominal ultrasonography, CT scan, MRI/MRCP scan, or endoscopic ultrasonography (EUS) Exclusion Criteria: * Pregnancy (self reported) * Presence of cholangitis before ERCP * Prior history of surgery on the stomach or duodenum that precludes conventional ERCP or prior biliary tree surgery (not including cholecystectomy) * Failure to selectively cannulate the bile duct * Life expectancy less than 30 days * Prisoners * Patients unable to give consent

What they're measuring

Technical success of CO2 cholangiography vs. iodinated contrast

Timeframe: Intraprocedural/immediate (during ERCP)

Trial details

NCT IDNCT02611453

SponsorUniversity of Virginia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12

View on ClinicalTrials.gov More Choledocholithiasis trials