Angiotensin Receptors and Age Related Mitochondrial Decline in HIV Patients

Inclusion Criteria: * able to provide informed consent * able to attend an extended (\~4 hour) Clinical Research Visit * documented HIV seropositivity * on a stable anti-retroviral therapy (ART) regimen for at least 12 months * HIV plasma viral load \< 50 copies/ml for at least 6 months * Systolic blood pressure \>110 Exclusion Criteria: * creatinine \> 1.5 ULN (or creatinine clearance \< 60 ml/min) * anti-hypertensive therapy with ACE-I or AT1R-blockers * inability to perform functional measures (e.g. non-ambulatory without assistance, requires a prosthesis) * recent (within 30 days) acute illness requiring medical therapy or hospitalization * immunosuppressive agents (e.g. \> 20 mg/d x 2 or more weeks of prednisone or equivalent, chemotherapy) in the last 6 months * cancer requiring treatment w/in 3 yrs (except for non-melanoma skin cancer) * blood thinning medications such as Coumadin or Plavix or a bleeding disorder such as hemophilia that could cause complications during muscle biopsies * pregnancy (will provide urine test for females of child bearing potential) * regular use of non-steroidal anti-inflammatory drugs or other immune modulating agents.