Chemo Sensitization Before Hematopoietic Stem Cell Transplantation in Patients With Acute Leukemia in Complete Remission

Inclusion Criteria: * Diagnosis of Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL), candidates to HSCT * Allogeneic HSCT: High risk AML in first complete remission (CR), AML in second CR, and ALL in first or second CR with a matched or half-matched (haploidentical) related or unrelated donor * Autologous HSCT: Intermediate risk AML in first CR, ALL in first or second CR without a donor * Normal liver function enzyme tests * Preserved renal function * Eastern Cooperative Oncology Group score ≤2 or Karnofsky ≥80% * Left ventricle ejection fraction (LVEF) \>40% * Hemoglobin (Hb) ≥ 10 g/dl, Absolute Neutrophil Count ≥ 1 x 103/mm3, and Platelets ≥ 100,000 /µL * Signed Informed Consent Exclusion Criteria: * Patients not willing to participate or to sign the informed consent * Patients who do not meet the inclusion criteria