WithdrawnPhase 1

Validation of Aspiration Markers in Intubated Patients

Stopped: Lack of funding

United States0Started 2015-12

Plain-language summary

The goal of this interventional study is to test Quinine as marker of aspiration (endotracheal tube \[ETT\] cuff leakage) in mechanically ventilated, critically ill patients.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Admission to Surgical ICUs (MGH Ellison 4 or Blake 12) * Patients expected to be intubated for at least 48 hours or longer from the time of enrollment. Exclusion Criteria: * High PEEP requirement at enrollment (PEEP higher than 8 cmH2O) * Diagnosis of ARDS (any severity) * Status asthmatics * Current or past participation in another interventional trial conflicting with the present study * Pregnant women * Prisoner status * Patients who had partial or total gastrectomy.

What they're measuring

Oropharyngeal aspiration: change in concentration of quinine in tracheal samples.

Timeframe: After the beginning of the study, samples will be collected at hours: 0,1 and 24, 25

Trial details

NCT IDNCT02598713

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-30

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