Tools for Therapeutic Evaluation in Charcot-Marie-Tooth Disease Type 1A: Outcome Measures and Biomarkers

Inclusion Criteria: * Patients with CMT 1A disease * Diagnosis of CMT 1A confirmed by genotyping (duplication of the 17p11.2 region) Exclusion Criteria: * Patients suffering from co-morbidity at the origin of peripheral neuropathy (diabetes, hypothyroidism, renal insufficiency, drugs...) or muscle, articular, rheumatological disease * With HIV or cancer * With a significant progressive disease in the previous month * With a contra-indication for MRI * With a dislocation, fracture, or recent surgery (less than 6 months before inclusion) * with alcohol or psychoactive substances abuse * Treated by an anti-inflammatory drug over the past four weeks * Pregnant or breastfeeding women * Homeless patients