Propranolol Dose Escalation in Lymphedema in Patients

Inclusion Criteria: * Primary lymphedema * Measurable disease * Adequate functional status: Karnofsky \>50% (\>age 16), Lanky \>50 (\<age 16), * No prior therapy within 4 weeks of enrollment * Adequate bone marrow, renal function, cardiac, and pulmonary function, negative pregnancy test (for women). Exclusion Criteria: * Secondary lymphedema * Patients already receiving other investigational drugs * Patients with known contraindications to receiving propranolol * Other medical comorbidities including but not limited to: pheochromocytoma, bradycardia, bronchospasm/reactive airway disease, decompensated heart failure, heart block, ongoing active infections.