Study of the Efficiency of Hydroxychloroquine on the Endothelial Dysfunction and Its Vascular Consequences During the Antiphospholipid Syndrome

Inclusion Criteria: * Patients who fulfilled Sidney criteria for APS (antiphospholipid Syndrome * Women of childbearing potential must have a contraceptive method * Written informed consent * no severe, progressive, or uncontrolled kidney, liver, blood, stomach, lung, heart, or brain disease. Exclusion Criteria: * secondary antiphospholipid syndrome * Pregnancy and breastfeeding * Patients with a history of severe depression, psychosis, or suicidal ideation * story of intolerance or contra-indication to hydroxychloroquine, lactose, trinitrin * Prior use of hydroxychloroquine in the last 6 months * Chronic heart failure * atrial fibrillation * severe pulmonary hypertension * severe kidney failure clearance \< 30ml/mn * uncontrolled arterial hypertension * secondary arterial hypertension * diabetes mellitus diagnosed in the last 3 months * body mass index \> 35 * Patient has been committed to an institution by legal or regulatory order