CompletedPhase 2

Implementing Treatment Algorithms for the Correction of Trauma Induced Coagulopathy

Denmark, Germany, Netherlands412 participantsStarted 2016-06-01

Plain-language summary

This trial compares the haemostatic effect of viscoelastic haemostatic assay (VHA)-guided transfusion strategy versus non-VHA guided transfusion strategy in haemorrhaging trauma patients. Half of the randomised patients will receive VHA-led management of bleeding, whilst the other half will receive massive transfusion protocol resuscitation using conventional coagulation tests.

Who can participate

Age range16 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Adult trauma patients (according to local definitions) will be enrolled if they: * Present with hemorrhagic shock at any time from the time of injury until admission to the emergency department (where shock is defined by HR\>100 b/min and/or systolic BP\<90 mmHg) AND activate the local massive transfusion protocol * Randomized within 3 hours of injury and 1 hour of admission to the emergency department * Agreement is provided on behalf of incapacitated patients by Personal Consultee or Nominated Consultee (e.g.trauma team leader) Exclusion Criteria: * Any inclusion criteria are not met

What they're measuring

Proportion of subjects alive and free of massive transfusion

Timeframe: 24 hours

Trial details

NCT IDNCT02593877

SponsorQueen Mary University of London

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-07-03

View on ClinicalTrials.gov More Hemorrhage trials