UnknownNot Applicable

Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder

Sweden50 participantsStarted 2015-10

Plain-language summary

This study evaluates underlying psychological and biological mediators in Internet-delivered cognitive behavior therapy for adults with social anxiety disorder.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Social Anxiety Disorder as primary diagnosis (DSM-5) * Otherwise somatically healthy * Willingness to participate in a symptom provocation brain imaging trial Exclusion Criteria: * Concurrent psychological treatment * Treatment of social anxiety within the three months preceding the study * Chronic use of prescribed medication that could influence the results (anxiolytic or antidepressant drugs, certain hypnotics or herbs like St Johns Wort) * Contraindications for MRI investigation (implants or other metal objects in the body, brain and heart operations) * Pregnancy or planned pregnancy during the first 6 months of the study period * Postmenopausal women * Any neurological disorders * Depressive symptoms, as determined by scoring more than 20 on the MADRS questionnaire (self-report version) * Suicidal ideation (scoring more than 2) on the self-report version of MADRS, item 9 * Suicide at moderate risk (MINI v7) * Bipolar disorder (MINI v7) * Psychotic syndromes (MINI v7) * Substance abuse disorders (MINI v7) * Alcohol abuse (MINI v7) * Any eating disorder (MINI v7) * Antisocial personality disorder (MINI v7)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Clinically Global Impression-Improvement scale (CGI-I; Change from baseline)

Timeframe: At week 20 (post-treatment), and at 6, 12, and 60 months

Liebowitz Social Anxiety Scale, Self-report version (LSAS-SR; Change from baseline)

Timeframe: Screening, Baseline 1 (week 0), Baseline 2 (week 9), weekly during treatment (week 10-19), week 20 (post-treatment), and at 6, 12, and 60 months

Trial details

NCT IDNCT02592564

SponsorLinkoeping University

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2017-04

View on ClinicalTrials.gov More Anxiety Disorders trials