UnknownNot Applicable

Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder

Sweden50 participantsStarted 2015-10

Plain-language summary

This study evaluates underlying psychological and biological mediators in Internet-delivered cognitive behavior therapy for adults with social anxiety disorder.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Social Anxiety Disorder as primary diagnosis (DSM-5) * Otherwise somatically healthy * Willingness to participate in a symptom provocation brain imaging trial Exclusion Criteria: * Concurrent psychological treatment * Treatment of social anxiety within the three months preceding the study * Chronic use of prescribed medication that could influence the results (anxiolytic or antidepressant drugs, certain hypnotics or herbs like St Johns Wort) * Contraindications for MRI investigation (implants or other metal objects in the body, brain and heart operations) * Pregnancy or planned pregnancy during the first 6 months of the study period * Postmenopausal women * Any neurological disorders * Depressive symptoms, as determined by scoring more than 20 on the MADRS questionnaire (self-report version) * Suicidal ideation (scoring more than 2) on the self-report version of MADRS, item 9 * Suicide at moderate risk (MINI v7) * Bipolar disorder (MINI v7) * Psychotic syndromes (MINI v7) * Substance abuse disorders (MINI v7) * Alcohol abuse (MINI v7) * Any eating disorder (MINI v7) * Antisocial personality disorder (MINI v7)

What they're measuring

Clinically Global Impression-Improvement scale (CGI-I; Change from baseline)

Timeframe: At week 20 (post-treatment), and at 6, 12, and 60 months

Liebowitz Social Anxiety Scale, Self-report version (LSAS-SR; Change from baseline)

Timeframe: Screening, Baseline 1 (week 0), Baseline 2 (week 9), weekly during treatment (week 10-19), week 20 (post-treatment), and at 6, 12, and 60 months

Trial details

NCT IDNCT02592564

SponsorLinkoeping University

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2017-04

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