The aim of this study is described as follows, 1. To establish a validated method to test cough reflex sensitivity conducted by transient receptor potential vanilloid 1(TRPV1). 2. To observe the variance of cough reflex sensitivity conducted by transient receptor potential ankyrin 1(TRPA1) of chronic patients and the relationship between cough reflex sensitivity conducted by TRPA1 and conducted by TRPV1. 3. To study the distribution of TRPA1 and TRPV1 channels and their relationship to cough reflex sensitivity.
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TRPA1,TRPV1 channels expression level of chronic cough patients and its relationship with cough reflex sensitivity
Timeframe: 7 days post-bronchoscopy