Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents

Inclusion Criteria: * Primary diagnosis of unipolar major depressive disorder, in a current major depressive episode, without psychotic features * Duration of current episode of depression ≥4 weeks and ≤3 years * Clinical Global Impression - Severity of Illness ≥ 4 * Resistance to antidepressant treatment in a discrete illness episode * HAMD24 Item 1 ≥ 2 and total score ≥ 20 * Subjects able to commit to protocol visit schedule * At the end of the baseline visit, subject must have a HAMD24 score of ≥ 18 and change in score may not be ≥ 25% decrease from that seen at the screening visit Exclusion Criteria: * Prior TMS, vagus nerve stimulation (VNS), or electroconvulsive therapy (ECT) * Contraindication to TMS * Cardiac pacemakers, implanted medication pumps, intracardiac lines * History of neurological disorder * Unstable medical conditions * Any psychiatric disorder, which in the judgement of the Investigator may hinder the subject in completing the procedures required by the study protocol. * Significant acute suicide risk * Inability to locate and quantify a motor threshold * If sexually active female, not on an accepted method of birth control. * Diagnoses of the following conditions (current unless otherwise stated): * Depression secondary to a general medical condition, or substance induced: * Seasonal pattern of depression as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM-5) * Any psychotic disorder (lifetime), including history of schizo…