TerminatedNot Applicable

Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors

Stopped: due to recent release reports from CDC about lung injury due to vaping, the PI and IRB decided to terminate the study

United States30 participantsStarted 2017-02-22

Plain-language summary

This aim will examine the acute and subacute exposures to electronic cigarette (EC) vapor generated from e-liquids without nicotine (NFEC) on life-time non smokers subjects by measuring changes in nasal ion transport and TGF-β levels. Nasal ion transport will be assessed by nasal potential difference (NPD). Tumor growth factor (TGF)-β levels (mRNA and protein by ELISA) will be assessed on nasal cells and lavages.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: INCLUSION CRITERIA: * Subjects will be over 18 years of age. * Healthy life-time non-smokers Exclusion Criteria: * Presence of airflow obstruction (COPD, asthma, bronchiectasis) * Other concomitant inflammatory pulmonary disorders * Subjects with known pulmonary malignancies within 5 years * Subjects with prior thoracic surgery * Subjects with respiratory infection that required use of oral corticosteroids and/or antibiotics within the prior 3 months * Subjects with allergies to study medications * Subjects incapable of providing informed consent.

What they're measuring

changes on nasal potential difference (NPD) measurements

Timeframe: before and after 7 days of vapor

Trial details

NCT IDNCT02585791

SponsorUniversity of Miami

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-11-11

View on ClinicalTrials.gov More Healthy Lifetime Non-smokers trials