Potentiation of Trauma Exposure in Post-traumatic Stress Disorder by Repeated Transcranial Magnet… (NCT02584894) | Clinical Trial Compass
CompletedNot Applicable
Potentiation of Trauma Exposure in Post-traumatic Stress Disorder by Repeated Transcranial Magnetic Stimulation
39 participantsStarted 2016-01-04
Plain-language summary
The aim of this study is to assess the efficacy in PTSD treatment of concomitant voluntary reactivation of personal traumatic memories with neuromodulation of the right dorsolateral prefrontal cortex using 10Hz rTMS, compared to 1Hz rTMS, during 2 weeks.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* PCLS score \>40
* Able to give his written informed consent
* Not participating another study
* Affiliation to a social security system
* Having a PTSD for 3 months
* No treatment modification for 4 weeks (Psychotropic treatment or structured psychotherapy)
Exclusion Criteria:
* Partially deaf with equipment
* people with identified neurological disease
* people with addiction to psychoactive substance
* people who can't conform to tests
* people having a contraindication for rTMS (cochlear implant )
* people suffering from chronicle or acute delusional disorder
* any circumstances making the people unable to understood nature, aim or consequences of the study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial used repeated Transcranial Magnetic Stimulation, or rTMS, combined with trauma exposure therapy to treat PTSD — can you explain how combining brain stimulation with exposure therapy might work differently than exposure therapy alone, and whether that approach would make sense for my situation?
2Since this trial is listed as 'Phase NA,' which often means it was an early or exploratory study focused on feasibility rather than large-scale proof of effectiveness, what does that mean for how confident we can be in the results, and how should that affect my thinking about this as a treatment option?
3The trial measured changes in PTSD symptoms using the Clinician-Administered PTSD Scale — do you know what the results actually showed, and whether the improvements seen were considered clinically meaningful for patients like me?
4This trial has already been completed, so if rTMS combined with exposure therapy showed promising results, is this approach currently available to me outside of a trial setting, or would I need to find another study that's still enrolling?
5How does this rTMS-plus-exposure-therapy approach compare to the standard PTSD treatments I might already be considering, like Prolonged Exposure therapy or medication, and would it make sense to try those first before exploring something like this?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from baseline Score at Clinician administered PTSD scale