The Effects of Early and Late Injection of Botulinum Toxin Type A on Upper Limb Function in Patients With Stroke

Inclusion Criteria: * stroke affecting one body side * spasticity develops after stroke Exclusion Criteria: * musculoskeletal conditions that affected upper limb function prior to stroke * concurrent use of anti-spasticity medications * patients with neuromuscular junction or myopathic disorders such as myasthenia gravis or others * patients with a known allergy to any onabotulinumtoxinA or to any of the excipients of onabotulinumtoxinA (such as human serum albumin) * patients who are pregnant or may become pregnant at the time of the proposed injection