Tumor Bed Hypofractionated IMRT After Surgery for Patients With Single,Large Brain Metastases From Solid Tumor

Inclusion Criteria: * Age \> 18 years * Karnosky performance status (KPS) ≥70 * All Solid tumor (esclusion SCLC and Germinal tumors) * Controlled primary tumor * Controlled other metastatic site * Single metastatic lesion at diagnosis * Lesions ≥ 2.1 cm in maximum diameter (4 cm3), \< 3 cm conditioning mass effect or neurological deficits or massive aedema, unknown primary tumor * Estimated survival ≥ 3 months. * Written informed consent Exclusion Criteria: * Prior WBRT * KPS ≤ 70 * Other primary cancer * Pregnant women