CompletedNot Applicable

Characterization of Auditory Processing Involved in the Encoding of Speech Sounds

France25 participantsStarted 2014-10-16

Plain-language summary

The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.

Who can participate

Age range6 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: For all subjects: * native French speaker * no medical treatment for behavior or neurological disorders * normal or corrected vision * right-handed * normal otorhinolaryngology examination * valid affiliation to social security * no participation to another research study For the normal-hearing subjects * normal tonal hearing thresholds * normal tympanometry For the subjects without specific language impairment * aged from 6 ro 40 * normal school attendance without scholastic retardation * normal intellectual level * normal for age reading skills * no delayed speech (expression \& production) For the children with specific language impairment * aged fom 8 to 18 * persistent specific literacy difficulties with reading levels at least 18 months behind that of their peers * normal intellectual level For the hearing impaired subjects * age from 18 to 70 * first auditory rehabilitation * bilateral and symmetric hearing loss (±10 dB) with hearing thresholds between 0 and 25 dB at 0.25 kilohertz, 0 and 35 dB at 0.5 kilohertz, 0 and 50 dB at 1 kilohertz, 25 and 70 dB at 2 kilohertz, 25 and 80 dB at 3 kilohertz, 30 and 80 dB at 4 kilohertz Exclusion Criteria: * non signed assent * treatment for depression, epilepsy, Parkinson's or alzheimer's disease during more than 6 months * physical health deficiency * mental retardation * neurological or psychiatric disease incompatible with testing procedure For children * known problem of hearing loss or chroni…

What they're measuring

Change from Baseline speech auditory brainstem and late responses (composite and objective measure) in response to syllables (behavioral measure)

Timeframe: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline

Trial details

NCT IDNCT02574299

SponsorHospices Civils de Lyon

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-03-01