Pain Relief In Irritable Bowel Syndrome

Inclusion criteria

• . patients over 18 y.o.
• . clinical diagnosis of IBS following Rome III symptom- based criteria:
• . abdominal pain or discomfort recurring for at least 3 days a month in the previous 3 months, associated with 2 of the following characteristics at least: improved with evacuation; onset associated with variation of stool frequency; onset associated with changes in stool consistency
• . onset of symptomatology at least 6 months preceding diagnosis
• . additional criterion: mean severity of abdominal pain higher than 3 in the 11-points NRS
• . For patients over 50 y.o. or with positive familiarity for colorectal cancer: normal colonoscopy performed within 5 years from the beginning of the screening's period and after symptomatology's onset
• . For patients over 65 y.o. : absence of ischemic / microscopic colitis, or other organic gastrointestinal disorders, as highlighted through colonoscopy with biopsy performed within 6 months from the beginning of the screening's period
• . For fertile and sexually active women: use of effective contraception with failure rate of less than 1% for one year during the trial period and 30 days after its end.

Exclusion criteria